Python 从大文件中特定出现的模式中提取名称
我有一个FASTA文件,它基本上是一个文本文件,用于描述生物序列数据(),包含10000多个FASTA序列(从>)。文件的开头如下所示:Python 从大文件中特定出现的模式中提取名称,python,r,bash,string-matching,Python,R,Bash,String Matching,我有一个FASTA文件,它基本上是一个文本文件,用于描述生物序列数据(),包含10000多个FASTA序列(从>)。文件的开头如下所示: >Gene A GAACTACACAAACGTAAAATGTAAAACAAAGGTATAAATTCCAGAAGTTGGACAGACATATATAGACAGCACATATATTA TCTTTATTTTTTTATGTATGATAACATTAAATATAACGTTCAACAATT >Gene B GAACTACACAAACGTAAAATGTAAAACAA
>Gene A
GAACTACACAAACGTAAAATGTAAAACAAAGGTATAAATTCCAGAAGTTGGACAGACATATATAGACAGCACATATATTA
TCTTTATTTTTTTATGTATGATAACATTAAATATAACGTTCAACAATT
>Gene B
GAACTACACAAACGTAAAATGTAAAACAAAGGTATAAATTCCAGAAGTTGGACAGACATATATAGACAGCACATATATTA
TCTTTATTTTTTTATGTATGATAACATTAAATATAACGTTCAACAATTACACCGTTAGCAGTGTGAGCAAAAACGATTAA
AAAGTAAATATTATAAAAGCCCTC
>Gene C
AACAACAAATTGCCATCTACCCGTTTGAATCCTGTAATAATAACTTGCCCAGATTTGCTGCAGCATACTCCTAGAGTTGG
GCTGGGTGGCCCACACAAGCGATAATAACATTTAACAATTGTTTGATATATGTACTTTTTTTTAAGTTTTTTTCTCCTCG
TACTTGCCTTCCAAAAACTCGTTAGCTTTGTACACATACGCCTTTAATTAAAATACTGATAGATGCGTACCACTTACGTC
ATTAGAAAAAGTCACCAAAAGGAAAAATATGGACGACACAAGAACGAGGAGATCTAAGCCACTCGTAGACCACTAAGCAC
AAAATACCCGAAAAATATAACTGATATGATTGCCAACTACCCTGCGACTATGTAAACCCAACCTTCCCCCCTCCTTTACC
CTCTTATTCAAATCGACGCGTGTGTAGAAGATACACTTATTATATTTTTTTTCTGAGATACAATTATAAACACAAAAACG
ACTTTTAACTATATATTAAATAAAAACAAAAGGAAAAACATAATAATTT
>Gene D
AACAACAAATTGCCATCTACCCGTTTGAATCCTGTAATAATAACTTGCCCAGATTTGCTGCAGCATACTCCTAGAGTTGG
GCTGGGTGGCCCACACAAGCGATAATAACATTTAACAATTGTTTGATATATGTACTTTTTTTTAAGTTTTTTTCTCCTCG
TACTTGCCTTCCAAAAACTCGTTAGCTTTGTACACATACGCCTTTAATTAAAATACTGATAGATGCGTACCACTTACGTC
ATTAGAAAAAGTCACCAAAAGGAAAAATATGGACGACACAAGAACGAGGAGATCTAAGCCACTCGTAGACCACTAAGCAC
AAAATACCCGAAAAATATAACTGATATGATTGCCAACTACCCTGCGACTATGTAAACCCAACCTTCCCCCCTCCTTTACC
CTCTTATTCAAATCGACGCGTGTGTAGAAGATACACTTATTATATTTTTTTTCTGAGATACAATTATAAACACAAAAACG
ACTTTTAACTATATATTAAATAAAAACAAAAGGAAAAACATAATAATTT
以此类推,大约有10000个基因。
我想:
grep '^>' file.txt > new_file.txt
但是我得到的输出是一个只包含所有基因名称的单一文件。这里有一个使用
stringi
包的R解决方案。由于没有单个文本文件或类似文件可作为可复制的示例访问,因此我使用cat()
和readlines()
读取表示您提供的行副本的临时文本。请同时检查计时基准,可能对大型文件感兴趣
sequences = open('fastafile.txt').read().split('>') # Creates a list of sequences.
needle = 'CTTTGTA'
occurrences = {}
for sequence in sequences:
occ = sequence.count(needle) # Returns the number of times the substring occurs in the string sequence.
if occ: # If greater than 0, create an entry in our dictionary. The sequence being the key and the count the value.
occurrences[sequence] = occ
output = []
sorted_occurrences = sorted(occurrences.items(), key=operator.itemgetter(1)) # Sort the dictionary by length, so sequences with the highest occurrence of the needle appear at the top.
for seq, occ_count in sorted_occurrences.iteritems():
gene_name, sequence = seq.split('\n')
formatted_line = '{gene_name} - {occ_count}'.format(gene_name=gene_name, occ_count=str(occ_count)) # Format the lines the way you want.
output.append(formatted_line)
with open('occurences.txt') as o_f:
o_f.write('\n'.join(output))
library(stringi)
cat(">Gene A
GAACTACACAAACGTAAAATGTAAAACAAAGGTATAAATTCCAGAAGTTGGACAGACATATATAGACAGCACATATATTA
TCTTTATTTTTTTATGTATGATAACATTAAATATAACGTTCAACAATT
>Gene B
GAACTACACAAACGTAAAATGTAAAACAAAGGTATAAATTCCAGAAGTTGGACAGACATATATAGACAGCACATATATTA
TCTTTATTTTTTTATGTATGATAACATTAAATATAACGTTCAACAATTACACCGTTAGCAGTGTGAGCAAAAACGATTAA
AAAGTAAATATTATAAAAGCCCTC
>Gene C
AACAACAAATTGCCATCTACCCGTTTGAATCCTGTAATAATAACTTGCCCAGATTTGCTGCAGCATACTCCTAGAGTTGG
GCTGGGTGGCCCACACAAGCGATAATAACATTTAACAATTGTTTGATATATGTACTTTTTTTTAAGTTTTTTTCTCCTCG
TACTTGCCTTCCAAAAACTCGTTAGCTTTGTACACATACGCCTTTAATTAAAATACTGATAGATGCGTACCACTTACGTC
ATTAGAAAAAGTCACCAAAAGGAAAAATATGGACGACACAAGAACGAGGAGATCTAAGCCACTCGTAGACCACTAAGCAC
AAAATACCCGAAAAATATAACTGATATGATTGCCAACTACCCTGCGACTATGTAAACCCAACCTTCCCCCCTCCTTTACC
CTCTTATTCAAATCGACGCGTGTGTAGAAGATACACTTATTATATTTTTTTTCTGAGATACAATTATAAACACAAAAACG
ACTTTTAACTATATATTAAATAAAAACAAAAGGAAAAACATAATAATTT
>Gene D
AACAACAAATTGCCATCTACCCGTTTGAATCCTGTAATAATAACTTGCCCAGATTTGCTGCAGCATACTCCTAGAGTTGG
GCTGGGTGGCCCACACAAGCGATAATAACATTTAACAATTGTTTGATATATGTACTTTTTTTTAAGTTTTTTTCTCCTCG
TACTTGCCTTCCAAAAACTCGTTAGCTTTGTACACATACGCCTTTAATTAAAATACTGATAGATGCGTACCACTTACGTC
ATTAGAAAAAGTCACCAAAAGGAAAAATATGGACGACACAAGAACGAGGAGATCTAAGCCACTCGTAGACCACTAAGCAC
AAAATACCCGAAAAATATAACTGATATGATTGCCAACTACCCTGCGACTATGTAAACCCAACCTTCCCCCCTCCTTTACC
CTCTTATTCAAATCGACGCGTGTGTAGAAGATACACTTATTATATTTTTTTTCTGAGATACAATTATAAACACAAAAACG
ACTTTTAACTATATATTAAATAAAAACAAAAGGAAAAACATAATAATTT
", file = "tempfile.txt")
genes <- readLines("tempfile.txt", n=-1)
unlink("tempfile.txt")
genes <- unlist(stri_split_fixed(paste(genes, collapse = " "), ">"))
genes <- genes[ genes != ""]
genenames <- unlist(stri_extract_all_regex(genes, "Gene \\w+"))
genes <- stri_replace_all_fixed(genes, genenames, "")
names(genes) <- genenames
genes <- gsub("\\s+", "", genes, perl = T)
gene_pattern_freq <- function(str, patterns) {
res <- sapply(patterns, function(p) {
stringi::stri_count_fixed(str, p)
}, USE.NAMES = T)
rownames(res) <- names(str)
return(res)
}
searchpatterns <- c("AA", "GT", "GAACTACACAAACGTAAAATGTAAAACAAAGGTATAAA")
result <- gene_pattern_freq(genes, searchpatterns)
result
# AA GT GAACTACACAAACGTAAAATGTAAAACAAAGGTATAAA
# Gene A 14 6 1
# Gene B 21 10 1
# Gene C 52 18 0
# Gene D 52 18 0
library(microbenchmark)
microbenchmark(gene_pattern_freq(genes, searchpatterns))
# Unit: microseconds
# expr min lq mean median uq max neval
# gene_pattern_freq(genes, searchpatterns) 68.687 77.371 123.438 78.161 79.345 4479.19 100
#export
write.csv(result, file = "../mypath/gene_pattern_freq_result.csv" )
库(stringi)
猫(“>基因A
GACTACACAAACGTAATGTAAAACACAAGGTATATAATTCACAGAGAGAGAGACAGATAGAGACAGATAGACAGATAGACAGATATATTA
TCTTTTTTTTTTTTATGTATGATACATAATATAACGTTCAAATT
>基因B
GACTACACAAACGTAATGTAAAACACAAGGTATATAATTCACAGAGAGAGAGACAGATAGAGACAGATAGACAGATAGACAGATATATTA
TCTTATTTTTTTTTATGTATATATATATATATACGTCACACATACACACACACCTTATAGTGATCACACACACACACACACACACACACACAGCATAGAGTGATCACACACACACACACACAACGATAA
AAAGTAAATATATAAAGCCCTC
>基因C
AACACAAATTGCCATCTACCCCGTTTGATCCTGTAATATATACTTGCCCAGATTGTGCAGCATCCTAGTAGTTGG
GCTGGGTGGCCCACAAGCGATAACATTTTAACATTTTTATATATGTTACTTTTAAGTTTTTTTCCG
TACTTGCCATCAAACTCGTTAGTTTGTACACACACACACAGCTTATTATATAAAATCTGATACGTACACACTCGTC
attagaaagtcaaagagaaagagaaagagagaaagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagag
aaaataccgaaaatataactgatgatgattgccaactacctgcgactatgttaaacccaacccttcccctcttac
CTCTTATTCAATCAATCAATCAAGCGTGTGTAGAAGATCACTTATTTTTTCTGAGAATCAATAACAATAACACAAAACG
动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作
>基因D
AACACAAATTGCCATCTACCCCGTTTGATCCTGTAATATATACTTGCCCAGATTGTGCAGCATCCTAGTAGTTGG
GCTGGGTGGCCCACAAGCGATAACATTTTAACATTTTTATATATGTTACTTTTAAGTTTTTTTCCG
TACTTGCCATCAAACTCGTTAGTTTGTACACACACACACAGCTTATTATATAAAATCTGATACGTACACACTCGTC
attagaaagtcaaagagaaagagaaagagagaaagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagag
aaaataccgaaaatataactgatgatgattgccaactacctgcgactatgttaaacccaacccttcccctcttac
CTCTTATTCAATCAATCAATCAAGCGTGTGTAGAAGATCACTTATTTTTTCTGAGAATCAATAACAATAACACAAAACG
动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作动作
,file=“tempfile.txt”)
欢迎来到“飞佬”的基因,如果答案有帮助的话,请把它标记为正确并考虑投票。谢谢更新了我的答案,以便它输出基因名而不是序列。好吧,这将适用于这些事件,但不适用于文件。除非他将文件内容粘贴到代码中,将每个序列声明为一个变量,并按照您的方式进行清理。您可能应该发布一个解决方案,打开有问题的文件并使用其内容而不是硬编码变量。@AlexisDevarenes发布的链接确实提供了一个文本文件作为可复制的示例,或者我遗漏了什么?在描述中,它说:有10000多个FASTA序列。所以我认为它的FAAAR比网站上显示的要大。我也找不到这个文本文件。@Manuel Bickel:我发布的链接只是对FASTA格式的描述。正如AlexisDevarenes正确指出的那样,我的实际文件中有10000多个条目。@AlexisDevarenes更新了我的答案,数据现在是示例行的副本。我还添加了一个基准,并对您的替换部件解决方案的基准感兴趣。Hi@alexisdevarenes。谢谢你可能的解决方案。但是,在运行脚本时,我得到了一个NameError:没有定义名称“sorted_事件”。如果我不排序,只是尝试获取列表(根据已排序的事件),那么我会得到:gene_name,sequence=seq.split('\n')value错误:太多的值无法解压,无法工作!!仍然是相同的NameError和ValueError